Novel and Objective Methods for Monitoring Neurodegenerative Disease

Speech disorder is an invisible form of disability

Adam Vogel

2016-01-01

How we sound influences how we are perceived physically, intellectually and morally. For individuals with a speech disorder (e.g.,..

An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels

EM Yiu, G Tai, RE Peverill, KJ Lee, KD Croft, TA Mori, B Scheiber-Mojdehkar, B Sturm, M Praschberger, AP Vogel, G Rance, SEM Stephenson, JP Sarsero, C Stockley, CYJ Lee, A Churchyard, MV Evans-Galea, MM Ryan, PJ Lockhart, LA Corben

2015-05-26

Friedreich ataxia (FRDA) is due to a triplet repeat expansion in FXN, resulting in deficiency of the mitochondrial protein frataxi..

Feasibility of automated speech sample collection with stuttering children using interactive voice response (IVR) technology

AP Vogel, S Block, E Kefalianos, M Onslow, P Eadie, B Barth, L Conway, JC Mundt, S Reilly

2015-04-01

Purpose: To investigate the feasibility of adopting automated interactive voice response (IVR) technology for remotely capturing s..

Development of precise tremor assessment software to aid deep brain stimulation parameter optimization

Thushara Perera, Shivanthan AC Yohanandan, Adam P Vogel, Colette M McKay, Hugh J McDermott

2015-03-01

A Systematic Review of Self-reported Swallowing Assessments in Progressive Neurological Disorders

M Keage, M Delatycki, L Corben, A Vogel

2015-02-01

Dysphagia experienced as a consequence of neurodegenerative disease can have severe consequences on a patient’s health and well-be..

Deep brain stimulation wash-in and wash-out times for tremor and speech

Thushara Perera, Shivanthan AC Yohanandan, Adam P Vogel, Colette M McKay, Mary Jones, Richard Peppard, Hugh J McDermott

2015-01-01

Parkinson’s disease (PD) and Essential Tremor (ET) are progressive conditions with high world-wide prevalence. Deep Brain Stimulat..

Dysphagia in spinocerebellar ataxia and multiple system atrophy-cerebellar

Adam P Vogel, Lori Fendel, K Paige Brubacher, Victoria Chan, Roxanne Maule

2015-01-01

Dysphagia is a common sequelae of spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar (MSA-C) resulting in signifi..

Nasality in Friedreich ataxia

ML Poole, JS Wee, JE Folker, LA Corben, MB Delatycki, AP Vogel

2015-01-01

Perceptual speech research in Friedreich ataxia (FRDA) has identified altered nasality as a key component of the dysarthria profil..

The feasibility of using acoustic markers of speech for optimizing patient outcomes during randomized amplitude variation in deep brain stimulation: a proof of principle methods study

A Vogel, H Mcdermott, T Perera, M Jones, R Peppard, C McKay

2015-01-01

Background: Deep brain stimulation (DBS) is an effective treatment for reducing symptoms of tremor. A common and typically subject..

The influence of rate of stimulation and pulse duration on efficacy of deep brain stimulation for Essential Tremor

CM McKay, HJ McDermott, T Perera, R Peppard, M Jones, AP Vogel

2015-01-01

Deep brain stimulation (DBS) is used to alleviate tremor in patients diagnosed with Essential Tremor who do not respond to convent..

Hand function is altered in individuals with a history of illicit stimulant use

V Pearson-Dennett, SC Flavel, RA Wilcox, D Thewlis, AP Vogel, JM White, G Todd

2014-12-29

Use of illicit stimulant drugs such as methamphetamine, cocaine, and ecstasy are a significant worldwide problem. However, little ..

Acoustic changes in the production of lexical stress during Lombard speech

J Arciuli, BS Simpson, AP Vogel, KJ Ballard

2014-06-01

The Lombard effect describes the phenomenon of individuals increasing their vocal intensity when speaking in the presence of backg..

Comparability of modern recording devices for speech analysis: Smartphone, landline, laptop, and hard disc recorder

AP Vogel, KM Rosen, AT Morgan, S Reilly

2014-05-06

Background: Large-scale multi-site experimental and clinical speech protocols require high-fidelity, easy-to-use speech recording ..

The relationship between speech motor control and cognition in prodomal and early stage Huntington's disease

AP Vogel, C Shirbin, AC Churchyard, J Stout

2014-05-01

Proportionate research funding based on relative burden of conditions of communication and swallowing

AP Vogel, SE Plant

2014-04-21

Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production

KJ Ballard, S Savage, CE Leyton, AP Vogel, M Hornberger, JR Hodges

2014-02-28

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet re..

Dysphagia and swallowing-related quality of life in Friedreich ataxia

AP Vogel, SE Brown, JE Folker, LA Corben, MB Delatycki

2014-01-01

Dysphagia in Friedreich ataxia (FRDA) and its impact on quality of life is not adequately understood. The objective of this study ..

Monitoring change requires a rethink of assessment practices in voice and speech

AP Vogel, P Maruff

2014-01-01

Assessment for the purpose of monitoring change over time requires a different practical and statistical approach to that of asses..

Speech

A VOGEL, M Loucas, L Rodriguez, P Guinti

2014-01-01

Swallowing

A VOGEL, M Loucas, L Rodriguez, P Guinti

2014-01-01

Systematic review of treatment options for dysarthria in hereditary ataxia syndromes

AP Vogel, JE Folker, ML Poole

2014-01-01

Objective: To evaluate the effectiveness of therapies for dysarthria in adults and children with Friedreich ataxia and other hered..

The impact of task automaticity on speech in noise

AV Vogel, J Fletcher, PT Maruff

2014-01-01

In the control of skeleto-motor movement, it is well established that the less complex, or more automatic a motor task is, the les..

Friedreich ataxia

P Gibilisco, AP Vogel

2013-12-03

This patient describes his experience of Friedreich ataxia, from diagnosis at 14 years old to being confined to a wheelchair for n..

Abstracts of the Seventeenth International Congress of Parkinson's Disease and Movement Disorders. June 16-20, 2013. Sydney, Australia.

2013-06-01

Swallowing function in people with Friedreich's ataxia

MJ Keage, L Corben, M Delatycki, AP Vogel

2013-06-01

Potential for optimising Deep Brain stimulation through tremor quantification

Thushara Perera, Colette McKay, Richard Peppard, Hugh McDermott, Adam Vogal

2013-01-01

Introduction: Deep Brain Stimulation (DBS) can be used to minimise tremor when pharmaceutical therapies fail. DBS devices emit a b..

Speech acoustic markers of early stage and prodromal Huntington's disease: A marker of disease onset?

AP Vogel, C Shirbin, AJ Churchyard, JC Stout

2012-12-01

Speech disturbances (e.g., altered prosody) have been described in symptomatic Huntington's Disease (HD) individuals, however, the..

Longitudinal change in dysarthria associated with Friedreich ataxia: A potential clinical endpoint

KM Rosen, JE Folker, AP Vogel, LA Corben, BE Murdoch, MB Delatycki

2012-11-01

CNS functions that show change across short periods of time are particularly useful clinical endpoints for Friedreich ataxia. This..

Vocal acoustic biomarkers of depression severity and treatment response

JC Mundt, AP Vogel, DE Feltner, WR Lenderking

2012-10-01

Background: Valid, reliable biomarkers of depression severity and treatment response would provide new targets for clinical resear..

Reliability, stability, and sensitivity to change and impairment in acoustic measures of timing and frequency

Adam P Vogel, Janet Fletcher, Peter J Snyder, Amy Fredrickson, Paul Maruff

2011-01-01

Assessment of the voice for supporting classifications of central nervous system (CNS) impairment requires a different practical, ..